CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Aurora kinase A

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O14965
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14965
AURKA_HUMAN
Homo sapiens
Aurora kinase A

PDB Structure

PDB 5DN3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.
Janecek, M., Rossmann, M., Sharma, P., Emery, A., Huggins, D.J., Stockwell, S.R., Stokes, J.E., Tan, Y.S., Almeida, E.G., Hardwick, B., Narvaez, A.J., Hyvonen, M., Spring, D.R., McKenzie, G.J., Venkitaraman, A.R.
Sci Rep