1 keywords

CATH Domain 5cr5A01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.470 D-amino Acid Aminotransferase; Chain A, domain 1
Homologous Superfamily 3.30.470.10 Aminotransferase class 4, branched-chain amino acid transferase, N-terminal domain

Domain Context

CATH Clusters

Superfamily 3.30.470.10
Functional Family Branched-chain-amino-acid aminotransferase

Enzyme Information

2.6.1.42
Branched-chain-amino-acid transaminase.
based on mapping to UniProt O15382
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
-!- Also acts on L-isoleucine and L-valine. -!- Different from EC 2.6.1.66.

UniProtKB Entries (1)

O15382
BCAT2_HUMAN
Homo sapiens
Branched-chain-amino-acid aminotransferase, mitochondrial

PDB Structure

PDB 5CR5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library.
Deng, H., Zhou, J., Sundersingh, F.S., Summerfield, J., Somers, D., Messer, J.A., Satz, A.L., Ancellin, N., Arico-Muendel, C.C., Sargent Bedard, K.L., Beljean, A., Belyanskaya, S.L., Bingham, R., Smith, S.E., Boursier, E., Carter, P., Centrella, P.A., Clark, M.A., Chung, C.W., Davie, C.P., Delorey, J.L., Ding, Y., Franklin, G.J., Grady, L.C., Herry, K., Hobbs, C., Kollmann, C.S., Morgan, B.A., Pothier Kaushansky, L.J., Zhou, Q.
Acs Med.Chem.Lett.