CATH Classification

Domain Context

CATH Clusters

Superfamily SRCR-like domain
Functional Family serine protease hepsin

Enzyme Information

3.4.21.106
Hepsin.
based on mapping to UniProt P05981
Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys.
-!- This type-II membrane-associated serine peptidase has been implicated in cell growth and development. -!- The enzyme has been shown to activate blood coagulation factor VII by cleavage of the 152-Arg-|-Ile-153 peptide bound in BHK cells, thus indicating a possible role in the initiation of blood coagulation. -!- There is no cleavage after aromatic or aliphatic residues. -!- The occupancy of the S2 site is an absolute requirement for catalysis and a basic residue at that site is preferred to an aliphatic residue. -!- The nature of the residue at S3 also affects hydrolysis, with Gln being much more favorable than Ala. -!- Belongs to peptidase family S1A.

UniProtKB Entries (1)

P05981
HEPS_HUMAN
Homo sapiens
Serine protease hepsin

PDB Structure

PDB 5CE1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Serine protease Hepsin in complex with Inhibitor
Rao, K.N., Anita, R.C., Sangeetha, R., Anirudha, L., Subramnay, H.
To Be Published