CATH Classification

Domain Context

CATH Clusters

Superfamily Malate synthase, domain III
Functional Family

Enzyme Information

2.3.3.9
Malate synthase.
based on mapping to UniProt P9WK17
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.
-!- The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. -!- Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2). -!- Formerly EC 4.1.3.2.

UniProtKB Entries (1)

P9WK17
MASZ_MYCTU
Mycobacterium tuberculosis H37Rv
Malate synthase G

PDB Structure

PDB 5CC6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of fragment-bound malate synthase from Mycobacterium tuberculosis provide insights into mechanism and potential inhibitor designs
Huang, H.-L., Krieger, I.V., Gawandi, V.B., Parai, M., Sacchettini, J.C.
To Be Published