CATH Classification

Domain Context

CATH Clusters

Superfamily tricorn interacting facor f3 domain
Functional Family Leucyl-cystinyl aminopeptidase

Enzyme Information

3.4.11.3
Cystinyl aminopeptidase.
based on mapping to UniProt Q9UIQ6
Release of an N-terminal amino acid, Cys-|-Xaa-, in which the half- cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.
-!- Belongs to peptidase family M1.

UniProtKB Entries (1)

Q9UIQ6
LCAP_HUMAN
Homo sapiens
Leucyl-cystinyl aminopeptidase

PDB Structure

PDB 5C97
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing.
Mpakali, A., Saridakis, E., Harlos, K., Zhao, Y., Papakyriakou, A., Kokkala, P., Georgiadis, D., Stratikos, E.
J Immunol.