CATH Classification

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase 10A

Enzyme Information

3.1.4.17
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt Q9Y233
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt Q9Y233
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

Q9Y233
PDE10_HUMAN
Homo sapiens
CAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

PDB Structure

PDB 5B4K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket
Yoshikawa, M., Hitaka, T., Hasui, T., Fushimi, M., Kunitomo, J., Kokubo, H., Oki, H., Nakashima, K., Taniguchi, T.
Bioorg.Med.Chem.