CATH Classification

Domain Context

CATH Clusters

Superfamily 1.25.40.10
Functional Family N-lysine methyltransferase SMYD2

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q9NRG4
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
2.1.1.-
Methyltransferases.
based on mapping to UniProt Q9NRG4

UniProtKB Entries (1)

Q9NRG4
SMYD2_HUMAN
Homo sapiens
N-lysine methyltransferase SMYD2

PDB Structure

PDB 5ARF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (Bay-598) for the Protein Lysine Methyltransferase Smyd2.
Eggert, E., Hillig, R.C., Kohr, S., Stockigt, D., Weiske, J., Barak, N., Mowat, J., Brumby, T., Christ, C.D., Ter Laak, A., Lang, T., Fernandez-Montalvan, A.E., Badock, V., Weinmann, H., Hartung, I.V., Barsyte-Lovejoy, D., Szewczyk, M., Kennedy, S., Li, F., Vedadi, M., Brown, P.J., Santhakumar, V., Arrowsmith, C.H., Stellfeld, T., Stresemann, C.
J.Med.Chem.