CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Cyclin-dependent kinase 2

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P24941
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24941
CDK2_HUMAN
Homo sapiens
Cyclin-dependent kinase 2

PDB Structure

PDB 5ANI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Automated Harvesting and Processing of Protein Crystals Through Laser Photoablation.
Zander, U., Hoffmann, G., Cornaciu, I., Marquette, J.-P., Papp, G., Landret, C., Seroul, G., Sinoir, J., Roewer, M., Felisaz, F., Rodriguez-Puente, S., Mariaule, V., Murphy, P., Mathieu, M., Cipriani, F., Marquez, J.A.
Acta Crystallogr.,Sect.D