CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoglycerate mutase-like
Functional Family 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2

Enzyme Information

3.1.3.46
Fructose-2,6-bisphosphate 2-phosphatase.
based on mapping to UniProt Q16875
Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
-!- The enzyme copurifies with EC 2.7.1.105 (cf. EC 3.1.3.54).
2.7.1.105
6-phosphofructo-2-kinase.
based on mapping to UniProt Q16875
ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.
-!- Not identical with EC 2.7.1.11. -!- The enzyme copurifies with EC 3.1.3.46.

UniProtKB Entries (1)

Q16875
F263_HUMAN
Homo sapiens
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

PDB Structure

PDB 5AK0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3.
Boyd, S., Brookfield, J.L., Critchlow, S.E., Cumming, I.A., Curtis, N.J., Debreczeni, J., Degorce, S.L., Donald, C., Evans, N.J., Groombridge, S., Hopcroft, P., Jones, N.P., Kettle, J.G., Lamont, S., Lewis, H.J., Macfaull, P., Mcloughlin, S.B., Rigoreau, L.J.M., Smith, J.M., St-Gallay, S., Stock, J.K., Turnbull, A.P., Wheatley, E.R., Winter, J., Wingfield, J.
J.Med.Chem.