CATH Classification

Domain Context

CATH Clusters

Superfamily Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Functional Family Leucine--tRNA ligase

Enzyme Information

6.1.1.4
Leucine--tRNA ligase.
based on mapping to UniProt P9WFV1
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

UniProtKB Entries (1)

P9WFV1
SYL_MYCTU
Mycobacterium tuberculosis H37Rv
Leucine--tRNA ligase

PDB Structure

PDB 5AGS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Palencia, A., Li, X., Bu, W., Choi, W., Ding, C.Z., Easom, E.E., Feng, L., Hernandez, V., Houston, P., Liu, L., Meewan, M., Mohan, M., Rock, F.L., Sexton, H., Zhang, S., Zhou, Y., Wan, B., Wang, Y., Franzblau, S.G., Woolhiser, L., Gruppo, V., Lenaerts, A.J., O'Malley, T., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Ioerger, T.R., Sacchettini, J.C., Rullas, J., Angulo-Barturen, I., Perez-Herran, E., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J., Alley, M.R.K.
Antimicrob.Agents Chemother.