CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.309 | Aldehyde Dehydrogenase; Chain A, domain 2 |
|
3.40.309.10 | Aldehyde Dehydrogenase; Chain A, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Aldehyde Dehydrogenase; Chain A, domain 2 |
| Functional Family | Mitochondrial aldehyde dehydrogenase 2 |
Enzyme Information
| 1.2.1.- |
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt P51977
|
| 1.2.1.36 |
Retinal dehydrogenase.
based on mapping to UniProt P51977
Retinal + NAD(+) + H(2)O = retinoate + NADH.
-!- Acts on both the 11-trans- and 13-cis-forms of retinal.
|
UniProtKB Entries (1)
| P51977 |
AL1A1_SHEEP
Ovis aries
Retinal dehydrogenase 1
|
PDB Structure
| PDB | 5AC1 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues.
Angew.Chem.Int.Ed.Engl.
|