CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Neutrophil elastase

Enzyme Information

3.4.21.37
Leukocyte elastase.
based on mapping to UniProt P08246
Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.
-!- Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.7 and EC 3.4.21.11.

UniProtKB Entries (1)

P08246
ELNE_HUMAN
Homo sapiens
Neutrophil elastase

PDB Structure

PDB 5A09
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
von Nussbaum, F., Li, V.M., Allerheiligen, S., Anlauf, S., Barfacker, L., Bechem, M., Delbeck, M., Fitzgerald, M.F., Gerisch, M., Gielen-Haertwig, H., Haning, H., Karthaus, D., Lang, D., Lustig, K., Meibom, D., Mittendorf, J., Rosentreter, U., Schafer, M., Schafer, S., Schamberger, J., Telan, L.A., Tersteegen, A.
ChemMedChem