CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family L-threonine 3-dehydrogenase, mitochondrial

Enzyme Information

1.1.1.103
L-threonine 3-dehydrogenase.
based on mapping to UniProt Q8K3F7
L-threonine + NAD(+) = L-2-amino-3-oxobutanoate + NADH.
-!- Acts in concert with EC 2.3.1.29 in the degradation of threonine to glycine. -!- This threonine-degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex. -!- In aqueous solution, the product L-2-amino-3-oxobutanoate can spontaneously decarboxylate to form aminoacetone.

UniProtKB Entries (1)

Q8K3F7
TDH_MOUSE
Mus musculus
L-threonine 3-dehydrogenase, mitochondrial

PDB Structure

PDB 4YRB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insights on mouse l-threonine dehydrogenase: A regulatory role of Arg180 in catalysis
He, C., Huang, X., Liu, Y., Li, F., Yang, Y., Tao, H., Han, C., Zhao, C., Xiao, Y., Shi, Y.
J.Struct.Biol.