CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.21
Coagulation factor VIIa.
based on mapping to UniProt P08709
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P13726
TF_HUMAN
Homo sapiens
Tissue factor

PDB Structure

PDB 4YLQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.
Sorensen, A.B., Madsen, J.J., Svensson, L.A., Pedersen, A.A., stergaard, H., Overgaard, M.T., Olsen, O.H., Gandhi, P.S.
J.Biol.Chem.