CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P01050
HIRV1_HIRME
Hirudo medicinalis
Hirudin variant-1

PDB Structure

PDB 4YES
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement.
Chobanian, H.R., Pio, B., Guo, Y., Shen, H., Huffman, M.A., Madeira, M., Salituro, G., Terebetski, J.L., Ormes, J., Jochnowitz, N., Hoos, L., Zhou, Y., Lewis, D., Hawes, B., Mitnaul, L., O'Neill, K., Ellsworth, K., Wang, L., Biftu, T., Duffy, J.L.
Acs Med.Chem.Lett.