1 keywords

CATH Domain 4y8cB00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1300 Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
Homologous Superfamily 1.10.1300.10 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase 9A

Enzyme Information

3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt O76083
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

O76083
PDE9A_HUMAN
Homo sapiens
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

PDB Structure

PDB 4Y8C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor.
Huang, M., Shao, Y., Hou, J., Cui, W., Liang, B., Huang, Y., Li, Z., Wu, Y., Zhu, X., Liu, P., Wan, Y., Ke, H., Luo, H.B.
Mol.Pharmacol.