CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Enzyme Information

1.1.1.267
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
based on mapping to UniProt Q8IKG4
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.

UniProtKB Entries (1)

Q8IKG4
DXR_PLAF7
Plasmodium falciparum 3D7
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic

PDB Structure

PDB 4Y67
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and Bioactivity of beta-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase.
Chofor, R., Sooriyaarachchi, S., Risseeuw, M.D., Bergfors, T., Pouyez, J., Johny, C., Haymond, A., Everaert, A., Dowd, C.S., Maes, L., Coenye, T., Alex, A., Couch, R.D., Jones, T.A., Wouters, J., Mowbray, S.L., Van Calenbergh, S.
J.Med.Chem.