CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Sepiapterin reductase

Enzyme Information

1.1.1.153
Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming).
based on mapping to UniProt P35270
(1) L-erythro-7,8-dihydrobiopterin + NADP(+) = sepiapterin + NADPH. (2) L-erythro-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8- tetrahydropterin + 2 NADPH.
-!- This enzyme catalyzes the final step in the de novo synthesis of tetrahydrobiopterin from GTP. -!- The enzyme, which is found in higher animals and some fungi and bacteria, produces the erythro form of tetrahydrobiopterin. -!- Cf. EC 1.1.1.325.

UniProtKB Entries (1)

P35270
SPRE_HUMAN
Homo sapiens
Sepiapterin reductase

PDB Structure

PDB 4XWY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.
Latremoliere, A., Latini, A., Andrews, N., Cronin, S.J., Fujita, M., Gorska, K., Hovius, R., Romero, C., Chuaiphichai, S., Painter, M., Miracca, G., Babaniyi, O., Remor, A.P., Duong, K., Riva, P., Barrett, L.B., Ferreiros, N., Naylor, A., Penninger, J.M., Tegeder, I., Zhong, J., Blagg, J., Channon, K.M., Johnsson, K., Costigan, M., Woolf, C.J.
Neuron