CATH Classification

Domain Context

CATH Clusters

Superfamily RNA polymerase, RBP11-like subunit
Functional Family DNA-directed RNA polymerase subunit alpha

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt A7ZSI4
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (3)

A8ARN6
RPOZ_CITK8
Citrobacter koseri ATCC BAA-895
DNA-directed RNA polymerase subunit omega
P00579
RPOD_ECOLI
Escherichia coli K-12
RNA polymerase sigma factor RpoD
A7ZUK1
RPOB_ECO24
Escherichia coli O139:H28 str. E24377A
DNA-directed RNA polymerase subunit beta

PDB Structure

PDB 4XSX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.
Bae, B., Nayak, D., Ray, A., Mustaev, A., Landick, R., Darst, S.A.
Proc.Natl.Acad.Sci.USA