CATH Classification

Domain Context

CATH Clusters

Superfamily Calcium-transporting ATPase, cytoplasmic domain N
Functional Family Sodium/potassium-transporting ATPase subunit alpha

Enzyme Information

7.2.2.13
Na(+)/K(+)-exchanging ATPase.
based on mapping to UniProt Q08DA1
ATP + H(2)O + Na(+)(Side 1) + K(+)(Side 2) = ADP + phosphate + Na(+)(Side 2) + K(+)(Side 1).
-!- P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- An enzyme from the plasma membrane of animal cells that catalyzes the efflux of three Na(+) and influx of two K(+) per ATP hydrolyzed. -!- It is involved in generating the plasma membrane electrical potential. -!- Formerly EC 3.6.1.37 and EC 3.6.3.9.

UniProtKB Entries (1)

G3MWR4
G3MWR4_BOVIN
Bos taurus
Sodium/potassium-transporting ATPase subunit beta

PDB Structure

PDB 4XE5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Isolation, crystallization and crystal structure determination of bovine kidney Na(+),K(+)-ATPase.
Gregersen, J.L., Mattle, D., Fedosova, N.U., Nissen, P., Reinhard, L.
Acta Crystallogr.,Sect.F