1 keywords

CATH Domain 4xe0A05

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1070 Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5
Homologous Superfamily 1.10.1070.11 Phosphatidylinositol 3-/4-kinase, catalytic domain

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-/4-kinase, catalytic domain
Functional Family Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit

Enzyme Information

2.7.1.153
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt O35904
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.

UniProtKB Entries (1)

O35904
PK3CD_MOUSE
Mus musculus
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

PDB Structure

PDB 4XE0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase delta.
Somoza, J.R., Koditek, D., Villasenor, A.G., Novikov, N., Wong, M.H., Liclican, A., Xing, W., Lagpacan, L., Wang, R., Schultz, B.E., Papalia, G.A., Samuel, D., Lad, L., McGrath, M.E.
J.Biol.Chem.