CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.10 | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
Domain Context
CATH Clusters
| Superfamily | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
| Functional Family | Carminomycin 4-O-methyltransferase DnrK |
Enzyme Information
| 2.1.1.292 |
Carminomycin 4-O-methyltransferase.
based on mapping to UniProt Q06528
S-adenosyl-L-methionine + carminomycin = S-adenosyl-L-homocysteine + daunorubicin.
-!- The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius are involved in the biosynthesis of the anthracycline daunorubicin. -!- In vitro the enzyme from Streptomyces sp. C5 also catalyzes the 4-O- methylation of 13-dihydrocarminomycin, rhodomycin D and 10-carboxy- 13-deoxycarminomycin.
|
UniProtKB Entries (1)
| Q06528 |
DNRK_STRPE
Streptomyces peucetius
Carminomycin 4-O-methyltransferase DnrK
|
PDB Structure
| PDB | 4WXH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis.
Proc.Natl.Acad.Sci.USA
|