CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Neutrophil elastase

Enzyme Information

3.4.21.37
Leukocyte elastase.
based on mapping to UniProt P08246
Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.
-!- Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.7 and EC 3.4.21.11.

UniProtKB Entries (1)

P08246
ELNE_HUMAN
Homo sapiens
Neutrophil elastase

PDB Structure

PDB 4WVP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Elastase-PK101 Structure: Mechanism of an Ultrasensitive Activity-based Probe Revealed.
Lechtenberg, B.C., Kasperkiewicz, P., Robinson, H., Drag, M., Riedl, S.J.
Acs Chem.Biol.