CATH Classification

Domain Context

CATH Clusters

Superfamily SET domain
Functional Family

Enzyme Information

2.1.1.-
Methyltransferases.
based on mapping to UniProt Q9NRG4
2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q9NRG4
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q9NRG4
SMYD2_HUMAN
Homo sapiens
N-lysine methyltransferase SMYD2

PDB Structure

PDB 4WUY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.
Nguyen, H., Allali-Hassani, A., Antonysamy, S., Chang, S., Chen, L.H., Curtis, C., Emtage, S., Fan, L., Gheyi, T., Li, F., Liu, S., Martin, J.R., Mendel, D., Olsen, J.B., Pelletier, L., Shatseva, T., Wu, S., Zhang, F.F., Arrowsmith, C.H., Brown, P.J., Campbell, R.M., Garcia, B.A., Barsyte-Lovejoy, D., Mader, M., Vedadi, M.
J.Biol.Chem.