CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome c-like domain
Functional Family

Enzyme Information

1.8.2.2
Thiosulfate dehydrogenase.
based on mapping to UniProt D3RVD4
2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c.
-!- The enzyme catalyzes the reversible formation of a sulfur-sulfur bond between the sulfane atoms of two thiosulfate molecules, yielding tetrathionate and releasing two electrons. -!- In many bacterial species the enzyme is a diheme c-type cytochrome. -!- In a number of organisms, including Thiomonas intermedia and Sideroxydans lithotrophicus, a second diheme cytochrome (TsdB) acts as the electron acceptor. -!- However, some organisms, such as Allochromatium vinosum, lack TsdB. -!- The electron acceptor in these organisms may be the high-potential iron-sulfur protein (HiPIP).

UniProtKB Entries (1)

D3RVD4
TSDA_ALLVD
Allochromatium vinosum DSM 180
Thiosulfate dehydrogenase

PDB Structure

PDB 4WQ8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Thiosulfate Dehydrogenase (TsdA) from Allochromatium vinosum: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO THIOSULFATE OXIDATION.
Brito, J.A., Denkmann, K., Pereira, I.A., Archer, M., Dahl, C.
J.Biol.Chem.