CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P43405
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P43405
KSYK_HUMAN
Homo sapiens
Tyrosine-protein kinase SYK

PDB Structure

PDB 4WNM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation.
Ferguson, G.D., Delgado, M., Plantevin-Krenitsky, V., Jensen-Pergakes, K., Bates, R.J., Torres, S., Celeridad, M., Brown, H., Burnett, K., Nadolny, L., Tehrani, L., Packard, G., Pagarigan, B., Haelewyn, J., Nguyen, T., Xu, L., Tang, Y., Hickman, M., Baculi, F., Pierce, S., Miyazawa, K., Jackson, P., Chamberlain, P., LeBrun, L., Xie, W., Bennett, B., Blease, K.
Plos One