CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Bifunctional polymyxin resistance protein ArnA

Enzyme Information

1.1.1.305
UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating).
based on mapping to UniProt P77398
UDP-alpha-D-glucuronate + NAD(+) = UDP-beta-L-threo-pentapyranos-4-ulose + CO(2) + NADH.
-!- The activity is part of a bifunctional enzyme also performing the reaction of EC 2.1.2.13. -!- Formerly EC 1.1.1.n1.
2.1.2.13
UDP-4-amino-4-deoxy-L-arabinose formyltransferase.
based on mapping to UniProt P77398
10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinose.
-!- The activity is part of a bifunctional enzyme also performing the reaction of EC 1.1.1.305. -!- Formerly EC 2.1.2.n1.

UniProtKB Entries (1)

P77398
ARNA_ECOLI
Escherichia coli K-12
Bifunctional polymyxin resistance protein ArnA

PDB Structure

PDB 4WKG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of apo ArnA features an unexpected central binding pocket and provides an explanation for enzymatic cooperativity.
Fischer, U., Hertlein, S., Grimm, C.
Acta Crystallogr.,Sect.D