1 keywords

CATH Domain 4wabA00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.120 Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous Superfamily 1.20.120.550 Membrane associated eicosanoid/glutathione metabolism-like domain

Domain Context

CATH Clusters

Superfamily Membrane associated eicosanoid/glutathione metabolism-like domain
Functional Family Microsomal glutathione S-transferase 1

Enzyme Information

5.3.99.3
Prostaglandin-E synthase.
based on mapping to UniProt O14684
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
-!- Brings about the opening of the epidioxy bridge.
4.4.1.20
Leukotriene-C(4) synthase.
based on mapping to UniProt Q16873
Leukotriene C(4) = leukotriene A(4) + glutathione.
-!- The reaction proceeds in the direction of addition. -!- Not identical with EC 2.5.1.18. -!- Formerly EC 2.5.1.37.

UniProtKB Entries (1)

O14684
PTGES_HUMAN
Homo sapiens
Prostaglandin E synthase

PDB Structure

PDB 4WAB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Fast native-SAD phasing for routine macromolecular structure determination.
Weinert, T., Olieric, V., Waltersperger, S., Panepucci, E., Chen, L., Zhang, H., Zhou, D., Rose, J., Ebihara, A., Kuramitsu, S., Li, D., Howe, N., Schnapp, G., Pautsch, A., Bargsten, K., Prota, A.E., Surana, P., Kottur, J., Nair, D.T., Basilico, F., Cecatiello, V., Pasqualato, S., Boland, A., Weichenrieder, O., Wang, B.C., Steinmetz, M.O., Caffrey, M., Wang, M.
Nat.Methods