CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.287.3610
Functional Family Diacylglycerol kinase

Enzyme Information

2.7.1.107
Diacylglycerol kinase (ATP).
based on mapping to UniProt P0ABN1
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
-!- Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. -!- Activity is stimulated by certain phospholipids. -!- In plants and animals the product 1,2-diacyl-sn-glycerol 3-phosphate is an important second messenger. -!- cf. EC 2.7.1.174.

UniProtKB Entries (1)

P0ABN1
KDGL_ECOLI
Escherichia coli K-12
Diacylglycerol kinase

PDB Structure

PDB 4UXZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Ternary Structure Reveals Mechanism of a Membrane Diacylglycerol Kinase.
Li, D., Stansfeld, P.J., Sansom, M.S.P., Keogh, A., Vogeley, L., Howe, N., Lyons, J.A., Aragao, D., Fromme, P., Fromme, R., Basu, S., Grotjohann, I., Kupitz, C., Rendek, K., Weierstall, U., Zatsepin, N.A., Cherezov, V., Liu, W., Bandaru, S., English, N.J., Gati, C., Barty, A., Yefanov, O., Chapman, H.N., Diederichs, K., Messerschmidt, M., Boutet, S., Williams, G.J., Marvin Seibert, M., Caffrey, M.
Nat.Commun.