CATH Classification

Domain Context

CATH Clusters

Superfamily C2 domain
Functional Family Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Enzyme Information

2.7.1.153
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt P48736
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P48736
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P48736
PK3CG_HUMAN
Homo sapiens
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PDB Structure

PDB 4URK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of 9-(1-Phenoxyethyl)-2-Morpholino-4-Oxo-Pyrido[1, 2-A]Pyrimidine-7-Carboxamides as Oral Pi3Kbeta Inhibitors, Useful as Antiplatelet Agents.
Giordanetto, F., Barlaam, B., Berglund, S., Edman, K., Karlsson, O., Lindberg, J., Nylander, S., Inghardt, T.
Bioorg.Med.Chem.Lett.