CATH Classification

Domain Context

CATH Clusters

Superfamily Cupin
Functional Family Lysine-specific demethylase 4A

Enzyme Information

1.14.11.-
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt O75164

UniProtKB Entries (1)

O75164
KDM4A_HUMAN
Homo sapiens
Lysine-specific demethylase 4A

PDB Structure

PDB 4URA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
England, K.S., Tumber, A., Krojer, T., Scozzafava, G., Ng, S.S., Daniel, M., Szykowska, A., Che, K., von Delft, F., Burgess-Brown, N.A., Kawamura, A., Schofield, C.J., Brennan, P.E.
Medchemcomm