CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.286.10
Functional Family GTP cyclohydrolase 1

Enzyme Information

3.5.4.16
GTP cyclohydrolase I.
based on mapping to UniProt Q8Y5X1
GTP + H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)-dihydropteridine triphosphate.
-!- The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic. -!- Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 4.2.3.12.

UniProtKB Entries (1)

Q8Y5X1
GCH1_LISMO
Listeria monocytogenes EGD-e
GTP cyclohydrolase 1

PDB Structure

PDB 4UQF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target.
Schussler, S., Haase, I., Perbandt, M., Illarionov, B., Siemens, A., Richter, K., Bacher, A., Fischer, M., Grawert, T.
Acta Crystallogr.,Sect.F