CATH Classification

Domain Context

CATH Clusters

Superfamily Nitric Oxide Synthase; Chain A, domain 3
Functional Family Nitric oxide synthase, brain

Enzyme Information

1.14.14.47
Nitric-oxide synthase (flavodoxin).
based on mapping to UniProt O34453
2 L-arginine + 3 reduced flavodoxin + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 oxidized flavodoxin + 4 H(2)O.
-!- The enzyme, found in bacteria and archaea, consist of only an oxygenase domain and functions together with bacterial ferredoxins or flavodoxins. -!- The orthologous enzymes from plants and animals also contain a reductase domain and use only NADPH as the electron donor (cf. EC 1.14.13.39). -!- Formerly EC 1.14.13.165.

UniProtKB Entries (1)

O34453
NOSO_BACSU
Bacillus subtilis subsp. subtilis str. 168
Nitric oxide synthase oxygenase

PDB Structure

PDB 4UGC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.
Holden, J.K., Dejam, D., Lewis, M.C., Huang, H., Kang, S., Jing, Q., Xue, F., Silverman, R.B., Poulos, T.L.
Biochemistry