CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family Peptidyl-prolyl cis-trans isomerase Pin1

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q13526
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q13526
PIN1_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

PDB Structure

PDB 4U85
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease.
Chen, C.H., Li, W., Sultana, R., You, M.H., Kondo, A., Shahpasand, K., Kim, B.M., Luo, M.L., Nechama, M., Lin, Y.M., Yao, Y., Lee, T.H., Zhou, X.Z., Swomley, A.M., Allan Butterfield, D., Zhang, Y., Lu, K.P.
Neurobiol.Dis.