CATH Domain 4u4sA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.190	D-Maltodextrin-Binding Protein; domain 2
	3.40.190.10	Periplasmic binding protein-like II

Domain Context

CATH Clusters

Superfamily	Periplasmic binding protein-like II
Functional Family	Glutamate receptor ionotropic, kainate 2

Enzyme Information

UniProtKB Entries (1)

GRIA2_RAT

Rattus norvegicus

Glutamate receptor 2

PDB Structure

PDB	4U4S
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides. Francotte, P., Nrholm, A.B., Deva, T., Olsen, L., Frydenvang, K., Goffin, E., Fraikin, P., de Tullio, P., Challal, S., Thomas, J.Y., Iop, F., Louis, C., Botez-Pop, I., Lestage, P., Danober, L., Kastrup, J.S., Pirotte, B. J.Med.Chem.