CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt Q00534
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (2)

Q01043
CGH2_SHV21
Herpesvirus saimiri (strain 11)
Cyclin homolog
Q00534
CDK6_HUMAN
Homo sapiens
Cyclin-dependent kinase 6

PDB Structure

PDB 4TTH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Li, Z., Wang, X., Eksterowicz, J., Gribble, M.W., Alba, G.Q., Ayres, M., Carlson, T.J., Chen, A., Chen, X., Cho, R., Connors, R.V., DeGraffenreid, M., Deignan, J.T., Duquette, J., Fan, P., Fisher, B., Fu, J., Huard, J.N., Kaizerman, J., Keegan, K.S., Li, C., Li, K., Li, Y., Liang, L., Liu, W., Lively, S.E., Lo, M.C., Ma, J., McMinn, D.L., Mihalic, J.T., Modi, K., Ngo, R., Pattabiraman, K., Piper, D.E., Queva, C., Ragains, M.L., Suchomel, J., Thibault, S., Walker, N., Wang, X., Wang, Z., Wanska, M., Wehn, P.M., Weidner, M.F., Zhang, A.J., Zhao, X., Kamb, A., Wickramasinghe, D., Dai, K., McGee, L.R., Medina, J.C.
J.Med.Chem.