CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family Iodothyronine deiodinase

Enzyme Information

1.21.99.3
Thyroxine 5-deiodinase.
based on mapping to UniProt Q91ZI8
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H(+) = L-thyroxine + reduced acceptor.
-!- The enzyme activity has only been demonstrated in the direction of 5-deiodination. -!- This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine. -!- Formerly EC 1.97.1.11.

UniProtKB Entries (1)

Q91ZI8
IOD3_MOUSE
Mus musculus
Thyroxine 5-deiodinase

PDB Structure

PDB 4TR4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism.
Schweizer, U., Schlicker, C., Braun, D., Kohrle, J., Steegborn, C.
Proc.Natl.Acad.Sci.USA