CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family LIM domain kinase 2

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P53671
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P53671
LIMK2_HUMAN
Homo sapiens
LIM domain kinase 2

PDB Structure

PDB 4TPT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation.
Goodwin, N.C., Cianchetta, G., Burgoon, H.A., Healy, J., Mabon, R., Strobel, E.D., Allen, J., Wang, S., Hamman, B.D., Rawlins, D.B.
Acs Med.Chem.Lett.