CATH Classification

Domain Context

CATH Clusters

Superfamily Topoisomerase I, domain 3
Functional Family DNA topoisomerase 1

Enzyme Information

5.6.2.2
DNA topoisomerase.
based on mapping to UniProt P06612
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.

UniProtKB Entries (1)

P06612
TOP1_ECOLI
Escherichia coli K-12
DNA topoisomerase 1

PDB Structure

PDB 4RUL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I.
Tan, K., Zhou, Q., Cheng, B., Zhang, Z., Joachimiak, A., Tse-Dinh, Y.C.
Nucleic Acids Res.