CATH Classification

Domain Context

CATH Clusters

Superfamily Serine-tRNA synthetase, tRNA binding domain
Functional Family Serine--tRNA ligase, cytoplasmic

Enzyme Information

6.1.1.11
Serine--tRNA ligase.
based on mapping to UniProt P49591
(1) ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). (2) ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).
-!- This enzyme also recognizes tRNA(Sec), the special tRNA for selenocysteine, and catalyzes the formation of L-seryl-tRNA(Sec), the substrate for EC 2.9.1.1.

UniProtKB Entries (1)

P49591
SYSC_HUMAN
Homo sapiens
Serine--tRNA ligase, cytoplasmic

PDB Structure

PDB 4RQE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
SerRS-tRNA Sec complex structures reveal mechanism of the first step in selenocysteine biosynthesis
Wang, C., Guo, Y., Tian, Q., Jia, Q., Gao, Y., Zhang, Q., Zhou, C., Xie, W.
Nucleic Acids Res.