CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotidyltransferases domain 2
Functional Family protein-tyrosine kinase 2-beta isoform X1

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q14289
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (2)

P49024
PAXI_CHICK
Gallus gallus
Paxillin
Q14289
FAK2_HUMAN
Homo sapiens
Protein-tyrosine kinase 2-beta

PDB Structure

PDB 4R32
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Mechanistic Insights into the Interaction between Pyk2 and Paxillin LD Motifs.
Vanarotti, M.S., Miller, D.J., Guibao, C.D., Nourse, A., Zheng, J.J.
J.Mol.Biol.