1 keywords

CATH Domain 4qo8D01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.720 NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family L-lactate dehydrogenase A chain

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt P00338
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

P00338
LDHA_HUMAN
Homo sapiens
L-lactate dehydrogenase A chain

PDB Structure

PDB 4QO8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Dragovich, P.S., Fauber, B.P., Boggs, J., Chen, J., Corson, L.B., Ding, C.Z., Eigenbrot, C., Ge, H., Giannetti, A.M., Hunsaker, T., Labadie, S., Li, C., Liu, Y., Liu, Y., Ma, S., Malek, S., Peterson, D., Pitts, K.E., Purkey, H.E., Robarge, K., Salphati, L., Sideris, S., Ultsch, M., VanderPorten, E., Wang, J., Wei, B., Xu, Q., Yen, I., Yue, Q., Zhang, H., Zhang, X., Zhou, A.
Bioorg.Med.Chem.Lett.