CATH Classification

Domain Context

CATH Clusters

Superfamily Lyase 2-enoyl-coa Hydratase, Chain A, domain 2
Functional Family 1,4-dihydroxy-2-naphthoyl-CoA synthase

Enzyme Information

4.1.3.36
1,4-dihydroxy-2-naphthoyl-CoA synthase.
based on mapping to UniProt P9WNP5
4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O.
-!- This enzyme is involved in the synthesis of 1,4-dihydroxy-2- naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K(2), in bacteria), phylloquinone (vitamin K(1) in plants), and many plant pigments. -!- The coenzyme A group is subsequently removed from the product by EC 3.1.2.28.

UniProtKB Entries (1)

P9WNP5
MENB_MYCTU
Mycobacterium tuberculosis H37Rv
1,4-dihydroxy-2-naphthoyl-CoA synthase

PDB Structure

PDB 4QIJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues
Song, H., Sung, H.P., Tse, Y.S., Jiang, M., Guo, Z.H.
Acta Crystallogr.,Sect.D