CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoglycerate mutase-like
Functional Family Glucosyl-3-phosphoglycerate phosphatase

Enzyme Information

3.1.3.85
Glucosyl-3-phosphoglycerate phosphatase.
based on mapping to UniProt P9WIC6
2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate + H(2)O = 2-O-(alpha- D-glucopyranosyl)-D-glycerate + phosphate.
-!- The enzyme is involved in biosynthesis of 2-O-(alpha-D- glucopyranosyl)-D-glycerate via the two-step pathway in which EC 2.4.1.266 catalyzes the conversion of GDP-glucose and 3-phospho-D- glycerate into 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D-glucopyranosyl)-D-glycerate by glucosyl-3-phosphoglycerate phosphatase. -!- In vivo the enzyme catalyzes the dephosphorylation of 2-O-(alpha-D- mannopyranosyl)-3-phospho-D-glycerate with lower efficiency. -!- Divalent metal ions (Mg(2+), Mn(2+) or Co(2+)) stimulate activity.
3.1.3.70
Mannosyl-3-phosphoglycerate phosphatase.
based on mapping to UniProt P9WIC6
2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2-O-(alpha-D- mannosyl)-D-glycerate + phosphate.
-!- The enzyme from Pyrococcus horikoshii is specific for alpha-D- mannosyl-3-phosphoglycerate and forms part of the pathway for the synthesis of mannosylglycerate.

UniProtKB Entries (1)

P9WIC6
GPGP_MYCTO
Mycobacterium tuberculosis CDC1551
Glucosyl-3-phosphoglycerate phosphatase

PDB Structure

PDB 4QIH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase
Zheng, Q., Jiang, D., Zhang, W., Zhang, Q., Zhao, Q., Jin, J., Li, X., Yang, H., Bartlam, M., Shaw, N., Zhou, W., Rao, Z.
J.Biol.Chem.