CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Thymidylate kinase

Enzyme Information

2.7.4.9
dTMP kinase.
based on mapping to UniProt Q6GJI9
ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

Q6GJI9
KTHY_STAAR
Staphylococcus aureus subsp. aureus MRSA252
Thymidylate kinase

PDB Structure

PDB 4QGF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Antibacterial inhibitors of gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region.
Kawatkar, S.P., Keating, T.A., Olivier, N.B., Breen, J.N., Green, O.M., Guler, S.Y., Hentemann, M.F., Loch, J.T., McKenzie, A.R., Newman, J.V., Otterson, L.G., Martinez-Botella, G.
J.Med.Chem.