CATH Classification

Domain Context

CATH Clusters

Superfamily Divalent-metal-dependent TIM barrel enzymes
Functional Family Xylose isomerase

Enzyme Information

5.3.1.5
Xylose isomerase.
based on mapping to UniProt P24300
D-xylopyranose = D-xylulose.
-!- The enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity. -!- The enzyme binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyzes ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. -!- Isomerization proceeds via a hydride-shift mechanism.

UniProtKB Entries (1)

P24300
XYLA_STRRU
Streptomyces rubiginosus
Xylose isomerase

PDB Structure

PDB 4QE1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
L-Arabinose Binding, Isomerization, and Epimerization by D-Xylose Isomerase: X-Ray/Neutron Crystallographic and Molecular Simulation Study.
Langan, P., Sangha, A.K., Wymore, T., Parks, J.M., Yang, Z.K., Hanson, B.L., Fisher, Z., Mason, S.A., Blakeley, M.P., Forsyth, V.T., Glusker, J.P., Carrell, H.L., Smith, J.C., Keen, D.A., Graham, D.E., Kovalevsky, A.
Structure