CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Glycogen synthase kinase 3

Enzyme Information
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P49841
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC and EC
[Tau protein] kinase.
based on mapping to UniProt P49841
ATP + [tau protein] = ADP + [tau protein] phosphate.
-!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Glycogen synthase kinase-3 beta

PDB Structure

External Links
Primary Citation
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Sivaprakasam, P., Han, X., Civiello, R.L., Jacutin-Porte, S., Kish, K., Pokross, M., Lewis, H.A., Ahmed, N., Szapiel, N., Newitt, J.A., Baldwin, E.T., Xiao, H., Krause, C.M., Park, H., Nophsker, M., Lippy, J.S., Burton, C.R., Langley, D.R., Macor, J.E., Dubowchik, G.M.