CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family L-lactate dehydrogenase

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt Q27743
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

Q27743
LDH_PLAFD
Plasmodium falciparum CDC/Honduras
L-lactate dehydrogenase

PDB Structure

PDB 4PLZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases.
Boucher, J.I., Jacobowitz, J.R., Beckett, B.C., Classen, S., Theobald, D.L.
Elife