CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Catechol O-methyltransferase

Enzyme Information

2.1.1.6
Catechol O-methyltransferase.
based on mapping to UniProt O88587
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.
-!- The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.

UniProtKB Entries (1)

O88587
COMT_MOUSE
Mus musculus
Catechol O-methyltransferase

PDB Structure

PDB 4P7F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mapping the conformational space accessible to catechol-O-methyltransferase.
Ehler, A., Benz, J., Schlatter, D., Rudolph, M.G.
Acta Crystallogr.,Sect.D