CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotide cyclase
Functional Family Adenylate cyclase type 10

Enzyme Information

4.6.1.1
Adenylate cyclase.
based on mapping to UniProt Q96PN6
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.

UniProtKB Entries (1)

Q96PN6
ADCYA_HUMAN
Homo sapiens
Adenylate cyclase type 10

PDB Structure

PDB 4OYP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket.
Saalau-Bethell, S.M., Berdini, V., Cleasby, A., Congreve, M., Coyle, J.E., Lock, V., Murray, C.W., O'Brien, M.A., Rich, S.J., Sambrook, T., Vinkovic, M., Yon, J.R., Jhoti, H.
Chemmedchem